What are Kryptopyrroles?

Often people with depression or other mental health issues have pyroluria, a disorder characterized by an abnormal over-production of a group of chemicals called kryptopyrroles. The pyrroles bind with vitamin B6, then zinc to deplete the body’s supply. Mood problems are a consequence of the vitamin B6 and zinc deficiencies which can be corrected with ongoing supplementation. Pyroluria seems to be a familial or genetic component, often with a family history of mental illness and all-girl families. Pyroluria is a stress-related condition and when symptoms are brought on by stress, pyroluria should be considered. Pyroluria may be present in 10% of the normal population, 30% of patients with attention-deficient hyperactive disorder (ADHD), 27% Schizophrenics as well as Autism and depression.

Characteristics of Pyroluria

  • Abdominal pain
  • Abnormal fat distribution
  • Acne, eczema, and herpes may also be present
  • Cold hands and feet
  • Explosive temper and mood swings
  • Fatigue
  • Fingernails- white marks, opaque and thin
  • Frequent ear infections as a child, as well as colds, fevers and chills. 
  • Hyperactivity
  • Impotence in males
  • Inability to tolerate drugs and alcohol
  • Insomnia and poor dream recall
  • Lack of regular periods in girls
  • Morning nausea and constipation
  • Nervous exhaustion
  • Pale skin
  • Poor memory or inability to think clearly
  • Seizures
  • Sensitivity to light and sound
  • Stretch marks in the skin
  • Not all the symptoms are present for every pyroluric but any number of them should make you suspicious.

Kryptopyrrole Testing

Sample Required: Urine sample with added supplied preservative.